Triggiani M, Oriente A, de Crescenzo G, Rossi G, Marone G
Division of Clinical Immunology and Allergy, University of Naples Federico II, Italy.
Int Arch Allergy Immunol. 1995 May-Jun;107(1-3):261-3. doi: 10.1159/000236997.
The distribution of arachidonic acid (AA) within intracellular lipid pools of inflammatory cells is thought to be an important factor regulating the production of eicosanoids. We have recently identified a pool of AA associated with triglycerides (TGs) in human lung macrophages. This pool is also present in other human inflammatory cells (mast cells, eosinophils, monocytes and platelets) and it contains a percentage of total cellular AA ranging from 10 to 45%. Kinetic studies of AA incorporation have shown that TG are the first acceptor pool for exogenous AA that is subsequently transferred to phospholipid pools. During cell activation, AA is released from phospholipids; however, a large amount of AA is rapidly reincorporated into TGs. The TG pool also supplies AA to the phospholipid pools once these have been depleted during cell activation. These data suggest that TGs are not only a storage site for AA but may also be important as regulators of AA metabolism and eicosanoid biosynthesis in human inflammatory cells.
花生四烯酸（AA）在炎症细胞内脂质池中的分布被认为是调节类花生酸生成的一个重要因素。我们最近在人肺巨噬细胞中发现了一个与甘油三酯（TGs）相关的AA池。这个池也存在于其他人类炎症细胞（肥大细胞、嗜酸性粒细胞、单核细胞和血小板）中，并且它占细胞总AA的百分比在10%到45%之间。AA掺入的动力学研究表明，TGs是外源性AA的第一个接受池，随后外源性AA会转移到磷脂池中。在细胞激活过程中，AA从磷脂中释放出来；然而，大量的AA会迅速重新掺入TGs中。一旦在细胞激活过程中磷脂池被耗尽，TG池也会向磷脂池供应AA。这些数据表明，TGs不仅是AA的储存位点，而且作为人类炎症细胞中AA代谢和类花生酸生物合成的调节因子可能也很重要。
