Borel Y, Fritsché R, Borel H, Dahlgren U, Dahlman-Höglund A, Telemo E, Hanson L A
Nestec Ltd. Research Centre, Lausanne, Switzerland.
Int Arch Allergy Immunol. 1995 May-Jun;107(1-3):264-7. doi: 10.1159/000236998.
Antigen presentation determines immunologic outcome, and by modifying the presentation of allergen to the host one can prevent an allergic response. Under certain conditions, covalent linkage, of ovalbumin to rat IgG, a molecule already tolerated by the host, can make a protein-IgG conjugate which down-regulates the immune response to this food allergen. The suppression is allergen specific. It affects both T and B cell immune responses. Administration of allergens linked to isologous IgG may provide a novel strategy for allergy prevention.
抗原呈递决定免疫结果，通过改变变应原向宿主的呈递方式可以预防过敏反应。在某些条件下，将卵清蛋白与宿主已经耐受的分子大鼠IgG共价连接，可以制成一种蛋白质-IgG结合物，该结合物可下调对这种食物变应原的免疫反应。这种抑制是变应原特异性的。它影响T细胞和B细胞的免疫反应。给予与同种IgG连接的变应原可能为预防过敏提供一种新策略。
