Ryu S J, Lin S K
Department of Neurology, Chang Gung Memorial Hospital, Taipei, Taiwan R.O.C.
J Formos Med Assoc. 1995 Jan-Feb;94(1-2):53-5.
Phenylpropanolamine (PPA) is the major ingredient of many over-the-counter cold remedies and diet pills. Use or abuse of PPA may cause hemorrhagic stroke or cerebral vasculitis similar to the clinical and angiographic picture associated with amphetamine use or abuse. We report a 32-year-old Taiwanese women who developed sudden onset of severe headache, nausea and vomiting on the seventh day of oral ingestion of 75 mg PPA per day. Cerebral angiograms showed multiple areas of alternating focal constriction and dilatation ("beading" appearance) in the anterior and posterior cerebral arteries consistent with cerebral arteritis. This case should alert medical practitioners to the potential hazards of over-the-counter drugs like PPA.
苯丙醇胺（PPA）是许多非处方感冒药和减肥药的主要成分。使用或滥用PPA可能会导致出血性中风或脑血管炎，其临床和血管造影表现与使用或滥用苯丙胺相似。我们报告了一名32岁的台湾女性，她在每天口服75毫克PPA的第7天突然出现严重头痛、恶心和呕吐。脑血管造影显示大脑前动脉和后动脉多处交替出现局灶性狭窄和扩张（“串珠样”表现），符合脑动脉炎。该病例应提醒医生注意PPA这类非处方药的潜在危害。
