Hammermeister K E, DeRouen T A, Dodge H T
Circulation. 1979 Mar;59(3):430-5. doi: 10.1161/01.cir.59.3.430.
Within the larger Seattle Heart Watch arteriography registry, surgically treated patients non randomly selected for direct myocardial revascularization were matched to medically treated patients such that each of the 287 pairs was identical in seven variables (ejection fraction, ventricular arrhythmia on resting electrocardiogram, age, heart murmur, stenosis of left main coronary artery greater than or equal to 50%, number of vessels with stenosis greater than or equal to 70%, and use of diuretics) previously demonstrated to be independently predictive of survival. Actuarial survival analyses based on cardiovascular deaths (average follow-up 3.5 years) indicate improved survival for the entire surgical matched pair cohort (p = 0.008) and for the surgically treated subgroup with two-vessel disease (p = 0.0002) when compared to the medical cohort. These results were confirmed by examination of the entire arteriography registry (n = 1524) in which these seven variables were known, using Cox's model for survival analysis. This multivariate, statistical technique indicated that the surgical mode of therapy was significantly predictive of improved survival in surgically treated patients for the entire registry (p = 0.008) and for the subgroup with two-vessel disease (p = 0.0005).
在规模更大的西雅图心脏观察血管造影登记处中，非随机选择接受直接心肌血运重建手术治疗的患者与接受药物治疗的患者进行匹配，使得287对中的每一对在七个变量（射血分数、静息心电图上的室性心律失常、年龄、心脏杂音、左主冠状动脉狭窄大于或等于50%、狭窄大于或等于70%的血管数量以及利尿剂的使用）上相同，这些变量先前已被证明可独立预测生存率。基于心血管死亡的精算生存分析（平均随访3.5年）表明，与药物治疗队列相比，整个手术匹配对队列（p = 0.008）以及患有双支血管疾病的手术治疗亚组（p = 0.0002）的生存率有所提高。通过对整个血管造影登记处（n = 1524）进行检查，使用Cox生存分析模型，其中这七个变量是已知的，这些结果得到了证实。这种多变量统计技术表明，手术治疗方式对于整个登记处接受手术治疗的患者（p = 0.008）以及患有双支血管疾病的亚组（p = 0.0005）的生存率提高具有显著预测性。
