Chu N S
Department of Neurology, Chang Gung Medical College and Memorial Hospital, Taipei, Taiwan ROC.
J Formos Med Assoc. 1995 Mar;94(3):106-10.
Betel chewing in man often produces palpitations, sweating, facial flushing and a warm sensation in the body. These observations suggest that betel chewing may affect the autonomic nervous system. To examine this, the RR interval variation (RRIV) was studied to determine if betel chewing might affect parasympathetic function. Three experimental groups of people consumed a betel nut preparation, betel quid and chewing gum, respectively. Recordings of RRIV were made before and during chewing. When one or two betel nut preparations were consumed, the main effect was a cardioacceleratory response. With increasing consumption of betel nut preparation, there was a reduction in RRIV, particularly during deep breathing. Consumption of betel quid or chewing gum had no effect on RRIV. The effect of betel chewing was dose-dependent. Consumption of a small amount caused cardioacceleratory response suggesting a sympathetic activation, while consumption of a large amount reduced RRIV, suggesting involvement of the parasympathetic function.
人类嚼食槟榔常常会产生心悸、出汗、面部潮红以及身体有温热感。这些观察结果表明，嚼食槟榔可能会影响自主神经系统。为了对此进行研究，对RR间期变异性（RRIV）进行了研究，以确定嚼食槟榔是否会影响副交感神经功能。三组实验对象分别食用槟榔制品、槟榔块和口香糖。在咀嚼前和咀嚼过程中记录RRIV。当食用一或两份槟榔制品时，主要影响是心脏加速反应。随着槟榔制品食用量的增加，RRIV降低，尤其是在深呼吸时。食用槟榔块或口香糖对RRIV没有影响。嚼食槟榔的效果呈剂量依赖性。少量食用会引起心脏加速反应，表明交感神经被激活，而大量食用会降低RRIV，表明副交感神经功能参与其中。
