Coleman A, Robertson G, Lugo T G
Division of Biomedical Sciences, University of California, Riverside 92521, USA.
Receptor. 1995 Spring;5(1):9-19.
The development of malignant melanoma is accompanied by an accumulation of genetic damage that is evident within tumor cells at both cytogenetic and molecular levels, and mutations at several gene loci are thought to contribute to malignant progression. Some of these loci are known oncogenes and tumor suppressor genes; others remain to be identified, although their chromosomal locations have been determined. Gene mapping studies indicate the presence of melanoma tumor suppressor genes on chromosomes 1, 6, and 9. The presence of a tumor suppressor gene on a particular chromosome can be demonstrated by transfer of an intact, normal copy of the chromosome into tumor cells. We have used this approach to investigate the mechanisms by which chromosome 6 suppresses the growth and tumorigenicity of human malignant melanoma cells.
恶性黑色素瘤的发展伴随着遗传损伤的积累，这在肿瘤细胞的细胞遗传学和分子水平上都很明显，并且几个基因位点的突变被认为有助于恶性进展。其中一些位点是已知的癌基因和肿瘤抑制基因；其他的仍有待确定，尽管它们的染色体位置已经确定。基因定位研究表明在1号、6号和9号染色体上存在黑色素瘤肿瘤抑制基因。通过将完整的正常染色体拷贝转移到肿瘤细胞中，可以证明特定染色体上存在肿瘤抑制基因。我们已经使用这种方法来研究6号染色体抑制人类恶性黑色素瘤细胞生长和致瘤性的机制。
