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[更年期激素替代疗法与神经并发症的预防]

[Menopausal hormone replacement therapy and prevention of neurologic complications].

作者信息

Lopes P, Mensier A, Laurent F X, Besse O

机构信息

Service de gynécologie-obstétrique A. hôp. femmes-enfants, Centre hospitalier régional et universitaire de Nantes.

出版信息

Contracept Fertil Sex. 1995 May;23(5):319-22.

PMID:7613577
Abstract

Aging of the population in industrialized countries, as a result of increased life expectancy, is associated with an increased risk of neurological diseases. Prevention of disability is one of the objectives of hormone replacement therapy of menopause (HRTM). Based on a review of the literature, the authors present the benefits of HRTM in terms of prevention of neurological complications. Estrogens directly and indirectly influence the neurological status. A decreased incidence of cerebrovascular accidents and dementia of the Alzheimer type and improvement of cognitive function in cases of dementia have been reported in several clinical and epidemiological papers. These data need to be confirmed by large-scale prospective studies conducted by epidemiologists and neurologists.

摘要

由于预期寿命延长,工业化国家的人口老龄化与神经疾病风险增加相关。预防残疾是更年期激素替代疗法(HRTM)的目标之一。基于文献综述,作者阐述了HRTM在预防神经并发症方面的益处。雌激素直接或间接影响神经状态。一些临床和流行病学论文报道,脑血管意外和阿尔茨海默型痴呆的发病率降低,以及痴呆患者认知功能改善。这些数据需要由流行病学家和神经学家进行的大规模前瞻性研究加以证实。

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