Vinatier D
Centre hospitalier universitaire de Lille.
Contracept Fertil Sex. 1995 May;23(5):327-34.
Integrins are a large family of cell surface proteins that serve as receptors, involved in cell-cell and cell-matrix interactions. These receptors are of fundamental importance in the organization of tissues and organs. Integrins participate in a complex apparatus anchoring cells to their surrounding and transducing signals into the cells. These signals regulate many important aspects of cell behaviour, including growth, differentiation and phenotype. Their roles in reproductive performance begin to be explored. It seems that all stages of reproduction involve integrins. During gametogenesis integrins let the gamete to receive the external informations. During fertilization integrins seem dramatically involved. Integrins are expressed in human endometrium. Endometrium integrin molecules appear to be regulated within the cycling endometrium and disruption of integrin expression may be associated with decreased uterine receptivity and infertility. Integrins are present on trophoblaste. A specific integrin type is expressed on invasive trophoblast. Low or absent expression of this specific type should be encountered during pre eclampsia. Probably the knowledge of these integrins will provide to the clinicians new diagnosis tools evaluating the quality of endometrium and of embryos.
整合素是一大类细胞表面蛋白，作为受体参与细胞间和细胞与基质的相互作用。这些受体在组织和器官的构成中至关重要。整合素参与一个复杂的机制，将细胞锚定到周围环境并将信号传导至细胞内。这些信号调节细胞行为的许多重要方面，包括生长、分化和表型。它们在生殖性能中的作用开始得到探索。似乎生殖的所有阶段都涉及整合素。在配子发生过程中，整合素使配子能够接收外部信息。在受精过程中，整合素似乎发挥了重要作用。整合素在人类子宫内膜中表达。子宫内膜整合素分子在周期性子宫内膜中似乎受到调节，整合素表达的破坏可能与子宫容受性降低和不孕有关。整合素存在于滋养层细胞上。一种特定类型的整合素在侵袭性滋养层细胞上表达。在子痫前期可能会出现这种特定类型整合素的低表达或不表达。或许对这些整合素的了解将为临床医生提供评估子宫内膜和胚胎质量的新诊断工具。
