Sueoka K, Shiokawa S, Miyazaki T, Kuji N, Tanaka M, Yoshimura Y
Keio University School of Medicine, Tokyo, Japan.
Fertil Steril. 1997 May;67(5):799-811. doi: 10.1016/s0015-0282(97)81388-x.
To review the available information regarding the role of integrins in reproductive physiology and to discuss their potential clinical implications.
Studies that specifically relate to the expression and modulation of integrins in fertilization, embryogenesis, and implantation were identified through the literature and Medline searches.
RESULT(S): Integrins are a class of adhesion molecules that participate in cell-to-cell and cell-to-substratum interactions and are present on essentially all human cells. All mammalian eggs express integrins at their surface, and the integrin alpha 6 beta 1 serves as a sperm receptor that mediates sperm-egg binding. In addition, certain integrin moieties appear to be regulated within the cycling endometrium. Specifically, the expression of beta 1 integrins in the early proliferative phase is restricted to the glandular epithelium, whereas stromal cells also express beta 1 integrins in the midsecretory phase. The expression of beta 1 integrins increases at the time of implantation and remains elevated in the decidua during early pregnancy. A disruption of integrin expression is associated with certain types of infertility in women. The apical surface of the mural trophectoderm does indeed possess functional integrins, and trophoblast interactions with extracellular matrix proteins largely depend on the integrin family of adhesion receptors.
CONCLUSION(S): Integrins play particularly important roles in both fertilization and embryogenesis, including the process of implantation.
回顾整合素在生殖生理学中的作用的现有信息，并讨论其潜在的临床意义。
通过文献检索和医学在线数据库检索，确定了与整合素在受精、胚胎发生和着床过程中的表达及调节相关的研究。
整合素是一类参与细胞间和细胞与基质相互作用的黏附分子，几乎存在于所有人类细胞上。所有哺乳动物的卵子在其表面都表达整合素，整合素α6β1作为精子受体介导精卵结合。此外，某些整合素部分在周期性子宫内膜中似乎受到调节。具体而言，β1整合素在增殖早期的表达仅限于腺上皮，而基质细胞在分泌中期也表达β1整合素。β1整合素的表达在着床时增加，并在妊娠早期的蜕膜中保持升高。整合素表达的破坏与女性的某些类型不孕症有关。壁滋养外胚层的顶端表面确实具有功能性整合素，滋养层与细胞外基质蛋白的相互作用很大程度上依赖于黏附受体的整合素家族。
整合素在受精和胚胎发生包括着床过程中发挥着特别重要的作用。
