Carter P S, de Ruiter A, Whatrup C, Katz D R, Ewings P, Mindel A, Northover J M
ICRF Colorectal Cancer Unit, St Mark's Hospital, London, UK.
Br J Surg. 1995 Apr;82(4):473-4. doi: 10.1002/bjs.1800820414.
The incidence of anal intraepithelial neoplasia (AIN) was studied in a group of 210 homosexual and bisexual men. The presence of genital warts and human immunodeficiency virus (HIV) infection was assessed as risk factors for the development of AIN. In all, 74 (35 per cent) of the group had histological evidence of AIN. The relative risk of being positive for HIV on AIN (relative to being negative for HIV) was 1.58 (95 per cent confidence interval (c.i.) 1.01-2.48). The relative risk of anal warts on AIN (relative to absence of anal warts) was 4.70 (95 per cent c.i. 1.81-12.20). Logistic regression analysis showed no significant interactive effect between HIV and anal warts on the risk of AIN. It is concluded from the results of a Mantel-Haenzel analysis that the presence of anal warts and HIV infection are independent risk factors for the development of AIN in homosexual and bisexual men.
对一组210名男同性恋者和双性恋男性的肛门上皮内瘤变（AIN）发病率进行了研究。评估了尖锐湿疣和人类免疫缺陷病毒（HIV）感染作为AIN发生的危险因素。该组中共有74人（35%）有AIN的组织学证据。AIN患者HIV检测呈阳性的相对风险（相对于HIV检测呈阴性者）为1.58（95%置信区间（c.i.）1.01 - 2.48）。AIN患者有肛门湿疣的相对风险（相对于无肛门湿疣者）为4.70（95% c.i. 1.81 - 12.20）。逻辑回归分析显示，HIV和肛门湿疣对AIN风险没有显著的交互作用。从Mantel-Haenzel分析结果得出结论，肛门湿疣和HIV感染是男同性恋者和双性恋男性发生AIN的独立危险因素。
