与甲状腺状态变化相关的早产断奶大鼠小肠乳糖酶活性自然下降延迟。

Delay in natural decline of lactase activity in the small intestine of prematurely weaned rats as related to changes in their thyroid status.

作者信息

Shinder D A, Rakhimov K R, Usmanova O D

机构信息

Laboratory of Digestive Physiology, Uzbekistan Academy of Science, Tashkent.

出版信息

Comp Biochem Physiol A Physiol. 1995 Jul;111(3):453-9. doi: 10.1016/0300-9629(95)00028-6.

DOI:10.1016/0300-9629(95)00028-6

PMID:7614038

Abstract

Premature weaning of suckling rats on the 15th day of life delayed the natural reduction of lactase activity in the small intestine and reduced the level of T4 in serum. Preliminary treatments (from day 12 to 14 of life) with exogenous T4 (1 mg/kg BW) or exposure to cold (10 degrees C) significantly increased the level of T4 in serum on the 15th day of life, and sharply accelerated the reduction of lactase activity. It is concluded that the delay in lactase reduction in prematurely weaned rats may be related to a decrease in serum thyroxine level. Cold as well as exogenous thyroxine may be considered as a means for regulation of the functional maturation of the small intestine.

摘要

出生后第15天对乳鼠进行过早断奶会延迟小肠乳糖酶活性的自然降低，并降低血清中T4的水平。在出生后第12至14天用外源性T4（1mg/kg体重）进行预处理或暴露于寒冷环境（10摄氏度）可显著提高出生后第15天血清中T4的水平，并急剧加速乳糖酶活性的降低。得出的结论是，过早断奶大鼠乳糖酶降低延迟可能与血清甲状腺素水平降低有关。寒冷以及外源性甲状腺素可被视为调节小肠功能成熟的一种手段。