Udelsman R, Li D G, Stagg C A, Holbrook N J
Laboratory of Endocrine Surgery, Johns Hopkins University School of Medicine, Baltimore, USA.
J Gerontol A Biol Sci Med Sci. 1995 Jul;50(4):B187-92. doi: 10.1093/gerona/50a.4.b187.
In previous studies we demonstrated that restraint, or immobilization stress, resulted in the induction of HSP70 mRNA in the vasculature of rats. This response was confined to the vascular smooth muscle, was associated with alpha 1-adrenergic receptor stimulation, and was attenuated with age. In the present study, we examined the influence of transplanting aged vessels into young animals and young vessels into aged animals to determine if this age-related diminution was due to changes intrinsic to the aorta or the result of alterations in the environment in which the aorta resides. We demonstrate that restraint-induced HSP70 expression in transplanted vessels is influenced to a greater degree by the age of the recipient than by the age of the transplanted vessel. Transplantation of aged vessels into young animals leads to preservation of the response, whereas transplantation of young vessels into aged animals leads to attenuation. These findings indicate that the environment in which the vessel resides is a major factor in determining this molecular response to stress.
在先前的研究中，我们证明了束缚或制动应激会导致大鼠血管中HSP70 mRNA的诱导。这种反应局限于血管平滑肌，与α1 - 肾上腺素能受体刺激有关，并且会随着年龄的增长而减弱。在本研究中，我们检查了将老龄动物的血管移植到幼龄动物体内以及将幼龄动物的血管移植到老龄动物体内的影响，以确定这种与年龄相关的减弱是由于主动脉本身的变化还是主动脉所处环境改变的结果。我们证明，移植血管中束缚诱导的HSP70表达受受体年龄的影响程度大于移植血管的年龄。将老龄动物的血管移植到幼龄动物体内可使反应得以保留，而将幼龄动物的血管移植到老龄动物体内则会导致反应减弱。这些发现表明，血管所处的环境是决定这种对应激分子反应的主要因素。
