某些1-苄基环烷基胺对大鼠的厌食和运动活性影响。
Anorectic and motor activity effects of some 1-benzylcycloalkylamines in the rat.
作者信息
Mrongovius R I, Ghosh P, Bolt A G
出版信息
Clin Exp Pharmacol Physiol. 1979 Jan-Feb;6(1):81-6. doi: 10.1111/j.1440-1681.1979.tb00010.x.
Abstract
- A series of 1-benzylcycloalkylamines with cycloalkyl rings of five, six or seven carbons and with various benzyl ring substituents (3-Cl, 4-Cl, 4-F, 3-CF3) was prepared and tested for anorectic and motor activity effects in rats. 2. Two potent, non-stimulant, anorectics were found: 1-(3-chlorobenzyl)-cycloheptylamine, and its N-methyl analogue. The activity of these compounds resembled that of chlorphentermine.
摘要
- 制备了一系列具有五个、六个或七个碳原子的环烷基环且带有各种苄基环取代基（3-氯、4-氯、4-氟、3-三氟甲基）的1-苄基环烷基胺，并在大鼠中测试其对食欲抑制和运动活性的影响。2. 发现了两种强效、非刺激性的食欲抑制剂：1-（3-氯苄基）环庚胺及其N-甲基类似物。这些化合物的活性与氯苯丁胺相似。
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