Danis V A, Millington M, Huang Q, Hyland V, Grennan D
Kolling Institute of Medical Research, Royal North Shore Hospital, University of Sydney, St. Leonards, NSW, Australia.
Dis Markers. 1995 Mar;12(2):135-9. doi: 10.1155/1994/464787.
Non-MHC linked genes may contribute to genetic predisposition to the development of systemic lupus erythematosus. The possibility that cytokine genes may be involved was raised by the observation of increased frequency in expression of an uncommon allele of an interleukin-1 receptor antagonist gene polymorphism and SLE in a recent U.K. study. We have not been able to show any significant differences in expression of this allele in SLE patients as a whole or in any patient subgroups. Our results actually show a slight decrease in the expression of this allele in SLE patients compared with healthy controls and in SLE patients with malar rash compared with SLE patients without malar rash.
非主要组织相容性复合体（MHC）连锁基因可能与系统性红斑狼疮发病的遗传易感性有关。最近一项英国研究发现，白细胞介素-1受体拮抗剂基因多态性的一种罕见等位基因表达频率增加与系统性红斑狼疮有关，这引发了细胞因子基因可能参与其中的可能性。我们未能在系统性红斑狼疮患者整体或任何患者亚组中显示该等位基因表达的任何显著差异。我们的结果实际上显示，与健康对照相比，系统性红斑狼疮患者中该等位基因的表达略有下降；与无颧部皮疹的系统性红斑狼疮患者相比，有颧部皮疹的系统性红斑狼疮患者中该等位基因的表达也略有下降。
