Liem W H, McCullough J L, Weinstein G D
Department of Dermatology, University of California at Irvine 92717, USA.
Cutis. 1995 May;55(5):306-10.
Topical therapy is the major treatment approach for patients with psoriasis. However, the effectiveness of available drugs (response rates and long-term maintenance) is not well known. This study investigated the current perceptions of American dermatologists on the effectiveness of topical medications for patients with mild or limited psoriasis. In a survey of 225 American dermatologists, class I to II topical steroids were regarded as most effective: 29 percent of dermatologists expected most of their patients to experience clearing of lesions when treated with these agents. Much lower response rates were found with medium and low-potency steroids, anthralin, or tars. The percentage of patients whose skin remained clear of lesions decreased to 50 percent while receiving maintenance corticosteroid therapy by three months and to 29 percent after one year. Topical corticosteroids were considered less effective than the available photo/systemic therapies by 79 percent of physicians. More effective topical modalities need to be developed to treat patients with mild/limited psoriasis.
局部治疗是银屑病患者的主要治疗方法。然而，现有药物的有效性（有效率和长期维持效果）尚不清楚。本研究调查了美国皮肤科医生目前对轻度或局限性银屑病患者局部用药有效性的看法。在一项对225名美国皮肤科医生的调查中，I至II级外用类固醇被认为是最有效的：29%的皮肤科医生预计，大多数患者使用这些药物治疗后皮损会消退。中效和低效类固醇、蒽林或焦油的有效率则低得多。接受维持性皮质类固醇治疗三个月后，皮肤无皮损的患者比例降至50%，一年后降至29%。79%的医生认为外用皮质类固醇不如现有的光疗/系统疗法有效。需要开发更有效的局部治疗方法来治疗轻度/局限性银屑病患者。
