Rowan A J, Shaywitz B A, Tuchman L, French J A, Luciano D, Sullivan C M
Department of Neurology, Department of Veterans Affairs Medical Center, Bronx, NY 10468, USA.
Epilepsia. 1995 Mar;36(3):270-5. doi: 10.1111/j.1528-1157.1995.tb00995.x.
The high intensity sweetener aspartame has been implicated anecdotally in seizure provocation. This possibility was investigated with a randomized, double-blind, placebo-controlled, cross-over study. After an extensive search, 18 individuals (16 adults and 2 children) who had seizures allegedly related to aspartame consumption were admitted to adult or pediatric epilepsy monitoring units where their EEG was monitored continuously for 5 days. Aspartame (50 mg/kg) or identically enpackaged placebo was administered in divided doses at 0800, 1000, and 1200 h on study days 2 and 4. All meals were uniformly standardized on treatment days. No clinical seizures or other adverse experiences were observed after aspartame ingestion. Mean plasma phenylalanine (Phe) concentrations increased significantly after aspartame ingestion (83.6 microM) as compared with placebo (52.3 microM). Results suggest that aspartame, in acute dosage of approximately 50 mg/kg, is no more likely than placebo to cause seizures in individuals who reported that their seizures were provoked by aspartame consumption.
高强度甜味剂阿斯巴甜一直被传闻与诱发癫痫发作有关。通过一项随机、双盲、安慰剂对照的交叉研究对这种可能性进行了调查。经过广泛搜索，18名据称癫痫发作与食用阿斯巴甜有关的个体（16名成年人和2名儿童）被收治到成人或儿科癫痫监测病房，在那里他们的脑电图被连续监测5天。在研究的第2天和第4天，于08:00、10:00和12:00分剂量给予阿斯巴甜（50毫克/千克）或包装相同的安慰剂。治疗日的所有膳食均统一标准化。摄入阿斯巴甜后未观察到临床癫痫发作或其他不良事件。与安慰剂（52.3微摩尔）相比，摄入阿斯巴甜后血浆苯丙氨酸（Phe）平均浓度显著升高（83.6微摩尔）。结果表明，对于那些报告其癫痫发作是由食用阿斯巴甜诱发的个体，大约50毫克/千克的急性剂量阿斯巴甜诱发癫痫发作的可能性并不比安慰剂更高。
