• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

gp120-induced programmed cell death in recently activated T cells without subsequent ligation of the T cell receptor.

作者信息

Foster S, Beverley P, Aspinall R

机构信息

Department of Medicine, St. Mary's Hospital Medical School, London, GB.

出版信息

Eur J Immunol. 1995 Jun;25(6):1778-82. doi: 10.1002/eji.1830250644.

DOI:10.1002/eji.1830250644
PMID:7615007
Abstract

In most individuals, HIV infection is characterized by a progressive decline in the number of peripheral blood CD4+ T lymphocytes, and while the number of CD4+ cells is within the normal range, defects in immune function are detectable. To date neither the decline in function nor the decline in cell number have been satisfactorily explained. Here we describe a mechanism which may contribute to the immunodeficiency and decline in CD4+ cell numbers in HIV-infected individuals. We show that recently activated T cells are susceptible to apoptosis when exposed to HIV gp120 in the presence of anti-gp120 antibody.

摘要

相似文献

1
gp120-induced programmed cell death in recently activated T cells without subsequent ligation of the T cell receptor.
Eur J Immunol. 1995 Jun;25(6):1778-82. doi: 10.1002/eji.1830250644.
2
Sensitization of T cells to CD95-mediated apoptosis by HIV-1 Tat and gp120.HIV-1 Tat和gp120使T细胞对CD95介导的细胞凋亡敏感。
Nature. 1995 Jun 8;375(6531):497-500. doi: 10.1038/375497a0.
3
Differential susceptibility to monomeric HIV gp120-mediated apoptosis in antigen-activated CD4+ T cell populations.抗原激活的CD4+ T细胞群体对单体HIV gp120介导的细胞凋亡的易感性差异。
Eur J Immunol. 1995 Oct;25(10):2907-16. doi: 10.1002/eji.1830251030.
4
Binding of HIV-1 virions or gp120-anti-gp120 immune complexes to HIV-1-infected quiescent peripheral blood mononuclear cells reveals latent infection.HIV-1病毒粒子或gp120-抗gp120免疫复合物与HIV-1感染的静止外周血单核细胞的结合揭示了潜伏感染。
J Immunol. 1996 May 15;156(10):3994-4004.
5
Are blockers of gp120/CD4 interaction effective inhibitors of HIV-1 immunopathogenesis?gp120/CD4相互作用的阻断剂是有效的HIV-1免疫发病机制抑制剂吗？
AIDS Rev. 2006 Jan-Mar;8(1):3-8.
6
Dexamethasone inhibits CD4 T cell deletion mediated by macrophages from human immunodeficiency virus-infected persons.地塞米松可抑制由人类免疫缺陷病毒感染者的巨噬细胞介导的CD4 T细胞耗竭。
J Infect Dis. 2001 Nov 15;184(10):1328-30. doi: 10.1086/323997. Epub 2001 Oct 2.
7
Programmed cell death in peripheral lymphocytes from HIV-infected persons: increased susceptibility to apoptosis of CD4 and CD8 T cells correlates with lymphocyte activation and with disease progression.HIV感染者外周淋巴细胞中的程序性细胞死亡：CD4和CD8 T细胞凋亡易感性增加与淋巴细胞活化及疾病进展相关。
J Immunol. 1996 May 1;156(9):3509-20.
8
The resistance of HIV-infected chimpanzees to progression to AIDS correlates with absence of HIV-related T-cell dysfunction.感染HIV的黑猩猩对艾滋病进展的抵抗力与不存在HIV相关的T细胞功能障碍相关。
J Med Primatol. 1993 Feb-May;22(2-3):194-200.
9
HIV envelope glycoprotein-induced cell killing by apoptosis is enhanced with increased expression of CD26 in CD4+ T cells.HIV包膜糖蛋白通过凋亡诱导的细胞杀伤作用，会随着CD4+T细胞中CD26表达的增加而增强。
Virology. 1996 Sep 15;223(2):318-30. doi: 10.1006/viro.1996.0483.
10
Fusion of human B cell lines with HIV-1 envelope-expressing T cells is enhanced by antigen-specific Ig receptors. Possible mechanism for elimination of gp120-specific B cells in vivo.抗原特异性Ig受体可增强人B细胞系与表达HIV-1包膜的T细胞的融合。体内消除gp120特异性B细胞的可能机制。
J Immunol. 1993 Mar 15;150(6):2506-16.

引用本文的文献

1
Detection of HIV gp120 in plasma during early HIV infection is associated with increased proinflammatory and immunoregulatory cytokines.在早期HIV感染期间，血浆中HIV gp120的检测与促炎和免疫调节细胞因子增加有关。
AIDS Res Hum Retroviruses. 2010 Oct;26(10):1139-45. doi: 10.1089/aid.2009.0290. Epub 2010 Aug 19.
2
Positive and negative aspects of the human immunodeficiency virus protease: development of inhibitors versus its role in AIDS pathogenesis.人类免疫缺陷病毒蛋白酶的正负两方面：抑制剂的研发与其在艾滋病发病机制中的作用
Microbiol Mol Biol Rev. 2000 Dec;64(4):725-45. doi: 10.1128/MMBR.64.4.725-745.2000.
3
Highly active anti-retroviral therapy (HAART) is associated with a lower level of CD4+ T cell apoptosis in HIV-infected patients.
高效抗逆转录病毒疗法（HAART）与HIV感染患者较低水平的CD4 + T细胞凋亡有关。
Clin Exp Immunol. 1999 Dec;118(3):412-6. doi: 10.1046/j.1365-2249.1999.01076.x.
4
T helper cell activation and human retroviral pathogenesis.辅助性T细胞激活与人类逆转录病毒发病机制。
Microbiol Rev. 1996 Dec;60(4):722-42. doi: 10.1128/mr.60.4.722-742.1996.
5
Protease-defective, gp120-containing human immunodeficiency virus type 1 particles induce apoptosis more efficiently than does wild-type virus or recombinant gp120 protein in healthy donor-derived peripheral blood T cells.蛋白酶缺陷型、含gp120的1型人类免疫缺陷病毒颗粒在健康供体来源的外周血T细胞中比野生型病毒或重组gp120蛋白更有效地诱导细胞凋亡。
J Clin Microbiol. 1997 Jan;35(1):41-7. doi: 10.1128/jcm.35.1.41-47.1997.
6
Envelope glycoproteins of human immunodeficiency virus type 1: profound influences on immune functions.1型人类免疫缺陷病毒的包膜糖蛋白：对免疫功能的深远影响。
Microbiol Rev. 1996 Jun;60(2):386-406. doi: 10.1128/mr.60.2.386-406.1996.