Last K S, Smith S, Pender N
Department of Clinical Dental Sciences, School of Dentistry, University of Liverpool, England.
Int J Oral Maxillofac Implants. 1995 Jan-Feb;10(1):58-66.
Determination of glycosaminoglycans (GAGs) in peri-implant sulcus fluid (PISF) may monitor tissue changes around implants. This study investigated osseointegrated IMZ titanium implants at five stages from initial exposure to occlusal loading from prostheses. Two peri-implant sulcus fluid glycosaminoglycans (PISF GAGs), hyaluronic acid (HA) and chondroitin-4 sulfate (CS), were determined by cellulose acetate electrophoresis and densitometric scanning. Compared to longer-serving implants, CS contents at early stages was higher and with full occlusal loading was three times greater, without significant changes in HA contents. These observations appeared to reflect predominantly responses in the supporting bone, particularly when compared to our previous studies on ceramic implants and teeth affected by periodontal disease. This study supports the potential of PISF GAG analysis to detect adverse tissue responses, notably bone resorption.
测定种植体周围龈沟液（PISF）中的糖胺聚糖（GAGs）可监测种植体周围组织的变化。本研究在从最初暴露到假体咬合加载的五个阶段，对骨结合型IMZ钛种植体进行了调查。通过醋酸纤维素电泳和光密度扫描测定了两种种植体周围龈沟液糖胺聚糖（PISF GAGs），即透明质酸（HA）和硫酸软骨素-4（CS）。与使用时间较长的种植体相比，早期阶段的CS含量更高，在完全咬合加载时高出三倍，而HA含量无显著变化。这些观察结果似乎主要反映了支持骨的反应，特别是与我们之前关于陶瓷种植体和受牙周病影响牙齿的研究相比。本研究支持PISF GAG分析检测不良组织反应，尤其是骨吸收的潜力。
