一名系统性红斑狼疮患者出现获得性蛋白S缺乏症，导致视网膜中央静脉血栓形成。
Acquired protein S deficiency in a patient with systemic lupus erythematosus causing central retinal vein thrombosis.
作者信息
Prince H M, Thurlow P J, Buchanan R C, Ibrahim K M, Neeson P J
机构信息
Department of Haematology, Austin Hospital, Heidelberg, Victoria, Australia.
出版信息
J Clin Pathol. 1995 Apr;48(4):387-9. doi: 10.1136/jcp.48.4.387.
Abstract
A 16 year old girl with systemic lupus erythematosus (SLE) developed the rare complication of central retinal vein occlusion. Although classically a disease of older patients, it has been recognised in association with SLE but only in the presence of the lupus anticoagulant or antiphospholipid antibodies. The thrombosis occurred when free protein S concentrations were transiently reduced and there was no family history or other known causes of reduced protein S concentrations. No other prothrombotic risk factors were present.
摘要
一名16岁的系统性红斑狼疮（SLE）女孩出现了视网膜中央静脉阻塞这一罕见并发症。虽然视网膜中央静脉阻塞通常是老年患者的疾病，但它已被认为与SLE有关，不过仅在存在狼疮抗凝物或抗磷脂抗体的情况下。血栓形成发生在游离蛋白S浓度短暂降低时，且不存在家族病史或其他已知的蛋白S浓度降低原因。不存在其他血栓形成的危险因素。
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本文引用的文献
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N Engl J Med. 1993 Jun 17;328(24):1753-7. doi: 10.1056/NEJM199306173282405.
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The role of abnormalities in the anticoagulant and fibrinolytic systems in retinal vascular occlusions.抗凝和纤溶系统异常在视网膜血管阻塞中的作用。
Surv Ophthalmol. 1993 Jan-Feb;37(4):283-92. doi: 10.1016/0039-6257(93)90011-u.
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Do medical conditions have an influence on central retinal vein occlusions?医学病症对视网膜中央静脉阻塞有影响吗？
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Total and free protein S in systemic lupus erythematosus.系统性红斑狼疮中的总蛋白S和游离蛋白S
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