通过脂多糖固相酶联免疫吸附测定（ELISA）鉴定的4例与产志贺毒素的O165型大肠杆菌（VTEC）相关的溶血尿毒综合征（HUS）病例

[Four cases of hemolytic uremic syndrome (HUS) associated with serotype O165 verotoxin producing Escherichia coli (VTEC) identified by LPS-solid phase enzyme-linked immunosorbent assay (ELISA)].

作者信息

Uchida H, Kanegane H, Yoshiya K, Kitamura K, Ihara T, Kamiya H, Kobayashi Y, Miyazawa H, Takeda T

机构信息

Department of Pediatrics, Kanazawa University.

出版信息

Kansenshogaku Zasshi. 1995 Jun;69(6):678-83. doi: 10.11150/kansenshogakuzasshi1970.69.678.

DOI:10.11150/kansenshogakuzasshi1970.69.678

PMID:7616014

Abstract

Enzyme-linked immunosorbent assay using LPS derived from newly recognized serotype O165 verotoxin producing Escherichia coli (VTEC) could identify 4 cases of hemolytic uremic syndrome (HUS) associated with O165 VTEC. All 4 cases showed a typical clinical course seen in VTEC-associated HUS. We screened 33 cases of HUS whose pathogen was not identified by culture of serodiagnosis. The O165 serotype was not thought to be important not only as a VTEC but also as an enteropathogenic E. coli. However, the prevalence, 4 cases, was as high as of O111 serotype, which is the second major serotype of VTEC in Japan. We have to be careful for this serotype when we look for the pathogen of the patients with hemorrhagic colitis or with HUS.

摘要

使用源自新确认的产志贺毒素大肠杆菌（VTEC）血清型O165的脂多糖进行酶联免疫吸附测定，可识别出4例与O165 VTEC相关的溶血性尿毒症综合征（HUS）病例。所有4例病例均呈现出VTEC相关HUS的典型临床病程。我们对33例经血清学诊断培养未鉴定出病原体的HUS病例进行了筛查。O165血清型不仅作为VTEC，而且作为肠致病性大肠杆菌，过去都未被认为是重要的。然而，4例的患病率与O111血清型一样高，O111血清型是日本VTEC的第二大主要血清型。在寻找出血性结肠炎或HUS患者的病原体时，我们必须对这种血清型保持警惕。