Morris E S, Elston C W, Bell J A, Galea M, Blamey R W, Ellis I O
Department of Histopathology, City Hospital, Nottingham, U.K.
J Pathol. 1995 May;176(1):55-62. doi: 10.1002/path.1711760109.
Immunohistochemical staining with the novel monoclonal antibody Ki-S1, believed to recognize a cell cycle-associated antigen, was investigated in 110 cases of invasive carcinoma of the breast. Immunoreactivity indices were compared with disease-free interval (DFI), overall survival, and a series of other prognostic indicators. Significant positive correlations were found between the percentage of strongly positive immunoreactive nuclei and tumour size, histological grade and type, vascular invasion, and mitotic count. A significant negative correlation was found with age. No significant correlation was found with either DFI or overall survival. Although a correlation with mitotic count does imply that the Ki-S1 antigen is cell cycle-associated to some extent, Ki-S1 does not appear to be a useful prognostic factor in human breast carcinoma.
采用新型单克隆抗体Ki-S1进行免疫组化染色，该抗体被认为可识别一种细胞周期相关抗原，对110例乳腺浸润癌进行了研究。将免疫反应指数与无病生存期（DFI）、总生存期以及一系列其他预后指标进行了比较。发现强阳性免疫反应细胞核的百分比与肿瘤大小、组织学分级和类型、血管侵犯以及有丝分裂计数之间存在显著正相关。与年龄存在显著负相关。与DFI或总生存期均未发现显著相关性。尽管与有丝分裂计数的相关性确实意味着Ki-S1抗原在某种程度上与细胞周期相关，但Ki-S1似乎并不是人类乳腺癌有用的预后因素。
