Clements G B, Galbraith D N, Taylor K W
Regional Virus Laboratory, Ruchill Hospital, Glasgow, UK.
Lancet. 1995 Jul 22;346(8969):221-3. doi: 10.1016/s0140-6736(95)91270-3.
Infection with Coxsackie B viruses has been linked to insulin-dependent diabetes mellitus. Nine of 14 serum samples (64%) taken from children at the onset of diabetes were positive for enterovirus RNA by PCR. All of the children were under age six, and five were under age three. By contrast, enterovirus sequences were detected in only two of 45 serum samples from appropriate comparison children (4%). Sequences from six of the positive patients showed strong homology with Coxsackie B3 and B4 viruses, and there were some common patterns among the sequences from infected diabetic children. This is evidence for a role for enteroviruses in childhood diabetes.
柯萨奇B病毒感染与胰岛素依赖型糖尿病有关。在糖尿病发病初期采集的14份儿童血清样本中，有9份（64%）通过聚合酶链反应检测出肠道病毒RNA呈阳性。所有儿童年龄均在6岁以下，其中5名年龄在3岁以下。相比之下，在45份来自适当对照儿童的血清样本中，只有2份检测出肠道病毒序列（4%）。6名阳性患者的序列与柯萨奇B3和B4病毒具有高度同源性，感染糖尿病儿童的序列之间存在一些共同模式。这证明肠道病毒在儿童糖尿病中发挥了作用。
