Ohsugi F, Yamada T, Tada S
Department of Radiology, Jikei University, School of Medicine.
Nihon Igaku Hoshasen Gakkai Zasshi. 1995 May;55(6):380-9.
Percutaneous transarterial implantation of a vascular access device (VAD) was used to treat advanced cervical carcinoma in 12 patients (IIb 3, IIIb 5, IVa 4). After altering intrapelvic flow by embolization under pelvic angiography, a 5 F catheter was placed in the internal iliac artery on the side of tumor dominance. RI angiography with 99mTc-MAA via the VAD showed 99% higher accumulation in the anterior division than in the posterior division of the pelvis. Consecutive infusion of cisplatin, 12.5 mg/body, via the VAD showed less toxicity than systemic chemotherapy. Overall response rate was 75% (CR 4, PR 5, NC 3). Curative surgical treatment was successful in nine of these 12 patients. This technique was evaluated to be effective for treatment of advanced cervical carcinoma.
采用经皮经动脉植入血管通路装置（VAD）治疗12例晚期宫颈癌患者（IIb期3例，IIIb期5例，IVa期4例）。在盆腔血管造影下通过栓塞改变盆腔内血流后，将一根5F导管置于肿瘤优势侧的髂内动脉。经VAD注入99mTc-MAA进行放射性核素血管造影显示，盆腔前部分的放射性积聚比后部分高99%。经VAD连续输注顺铂，剂量为12.5mg/体，其毒性低于全身化疗。总缓解率为75%（完全缓解4例，部分缓解5例，疾病稳定3例）。这12例患者中有9例成功接受了根治性手术治疗。该技术被评估对晚期宫颈癌治疗有效。
