Yamada T, Ohsugi F, Irie T, Ishii C, Sadaoka S, Tada S
Department of Radiology, The Jikei University School of Medicine, 3-25-8, Nishi-shinbashi, Minato-ku, Tokyo, 105 Japan.
Cardiovasc Intervent Radiol. 1996 May-Jun;19(3):139-45. doi: 10.1007/BF02577609.
Twenty-two patients with advanced gynecologic cancer underwent extended intraarterial cisplatin infusion after alteration of the intrapelvic blood flow and implantation of a vascular access device (VAD).
To maximize concentrations of cisplatin at the target lesion, the superior and inferior gluteal arteries were embolized with steel coils. The tip of the catheter was inserted into the internal iliac artery; the opposite end of the catheter was connected to the VAD.
Intensive radioisotope accumulation was demonstrated in the anterior division of the pelvis, seen by scintigraphy performed with technetium 99m macroaggregated albumin via the VAD. Local perfusion in the tumor was well seen by ultrasonographic angiography with CO2 microbubbles via the VAD. Continuous consecutive infusion of cisplatin at a rate of 12.5 mg/day via the VAD minimized the toxicity. The overall response rate was 73%. Radical surgery was possible in 16 of the 22 patients after this intraarterial infusion.
This method was useful for treating advanced gynecologic cancer without significant toxicity.
22例晚期妇科癌症患者在盆腔血流改变并植入血管通路装置（VAD）后接受了动脉内顺铂延长输注。
为使顺铂在靶病变处的浓度最大化，用钢圈栓塞臀上动脉和臀下动脉。将导管尖端插入髂内动脉；导管另一端连接到VAD。
通过经VAD注入99m锝标记的大颗粒白蛋白进行闪烁扫描，显示盆腔前部有密集的放射性同位素聚集。通过经VAD注入二氧化碳微泡进行超声血管造影，可以很好地观察到肿瘤的局部灌注情况。通过VAD以每天12.5毫克的速率持续连续输注顺铂可将毒性降至最低。总体缓解率为73%。在进行这种动脉内输注后，22例患者中有16例可行根治性手术。
该方法可有效治疗晚期妇科癌症且无明显毒性。
