Meguro K, Yanai K, Sakai N, Sakurai E, Maeyama K, Sasaki H, Watanabe T
Department of Geriatric Medicine, Tohoku University School of Medicine, Sendai, Japan.
Pharmacol Biochem Behav. 1995 Mar;50(3):321-5. doi: 10.1016/0091-3057(95)00248-u.
The effect of thioperamide, a histamine H3 receptor antagonist, on learning and memory was studied in the senescence-accelerated mice-prone strain (SAM-P/8) and normal-rate aging strain (SAM-R/1). In a passive avoidance test, SAM-P/8 mice of 12 months showed significant impairment of learning and memory compared with SAM-R/1 mice of the same age. Thioperamide significantly improved the response latency in SAM-P/8 mice when injected intraperitoneally at a dose of 15 mg/kg. The histidine decarboxylase (HDC) activity in the forebrain was significantly lower in SAM-P/8 mice than in SAM-R/1 mice. Thioperamide administration significantly potentiated HDC activity in the forebrain of SAM-P/8 mice as well as improving learning and memory. These results suggest that central histaminergic neurons may be involved in learning and memory impairment of SAM-P/8 mice, although other possibilities are not ruled out.
研究了组胺H3受体拮抗剂硫代酰胺对快速老化小鼠易感亚系（SAM-P/8）和正常老化亚系（SAM-R/1）学习和记忆的影响。在被动回避试验中，12月龄的SAM-P/8小鼠与同龄的SAM-R/1小鼠相比，学习和记忆能力显著受损。硫代酰胺以15mg/kg的剂量腹腔注射时，可显著提高SAM-P/8小鼠的反应潜伏期。SAM-P/8小鼠前脑的组氨酸脱羧酶（HDC）活性显著低于SAM-R/1小鼠。给予硫代酰胺可显著增强SAM-P/8小鼠前脑的HDC活性，并改善其学习和记忆能力。这些结果表明，中枢组胺能神经元可能参与了SAM-P/8小鼠的学习和记忆损伤，尽管其他可能性也不能排除。
