Varlinskaya E I, Petrov E S, Robinson S R, Smotherman W P
Pavlovian Physiological Department, Russian Academy of Medical Sciences, St. Petersburg.
Pharmacol Biochem Behav. 1995 Mar;50(3):359-67. doi: 10.1016/0091-3057(94)00273-l.
The dopamine D1 agonist SKF-38393 and the D1 antagonist SCH-23390 were administered into the left or right cerebral hemisphere of the rat fetus on E21 of gestation. Intrahemispheric (IH) injection of the agonist promoted a large-magnitude increase in fetal motor behavior, which involved movements of the head, limbs, and body trunk. Although no lateral asymmetries were evident in left or right injections of the agonist, IH injection of the antagonist into the fetus's left hemisphere produced more pronounced effects on oral behavior, including mouth, lick, and facial wipe movements. Administration of SCH-23390 into the same hemisphere as SKF-38393 was effective in reversing the behavioral effects of the agonist, with left IH injections showing more immediate and complete blockade of agonist-induced behavioral activation. These data provide evidence for functional asymmetries in D1 receptors of the dopamine system in the term rat fetus.
在妊娠第21天，将多巴胺D1激动剂SKF - 38393和D1拮抗剂SCH - 23390注入大鼠胎儿的左或右大脑半球。半球内（IH）注射激动剂可使胎儿运动行为大幅增加，包括头部、四肢和躯干的运动。虽然激动剂左右注射时未表现出明显的侧向不对称，但向胎儿左半球进行IH注射拮抗剂对口腔行为（包括嘴部、舔舐和面部擦拭动作）产生的影响更为显著。将SCH - 23390与SKF - 38393注入同一半球可有效逆转激动剂的行为效应，左半球IH注射显示对激动剂诱导的行为激活有更迅速和完全的阻断作用。这些数据为足月大鼠胎儿多巴胺系统D1受体的功能不对称提供了证据。
