Varlinskaya E I, Petrov E S, Robinson S R, Smotherman W P
Pavlovian Physiological Department, Russian Academy of Medical Sciences, St. Petersburg.
Pharmacol Biochem Behav. 1994 Jul;48(3):741-8. doi: 10.1016/0091-3057(94)90341-7.
The dopamine D1 agonist SKF-38393 and the D1 antagonist SCH-23390 were administered into the central nervous system of the E21 rat fetus via intracisternal (IC) injection. IC injection of SKF-38393 promoted a dose-dependent increase in fetal motor activity, principally including movements of the forelimbs, head, and body trunk. IC injection of SCH-23390 did not affect overall activity, but selectively suppressed forelimb, rearlimb, and head movements and promoted an increase in mouthing, licking, and facial wiping. Administration of SCH-23390 after IC injection of SKF-38393 was effective in completely reversing the behavioral effects of the D1 agonist. These findings suggest that central manipulation of dopamine D1 receptors can have direct and potent behavioral effects in the term rat fetus.
通过脑池内（IC）注射，将多巴胺D1激动剂SKF - 38393和D1拮抗剂SCH - 23390注入E21大鼠胎儿的中枢神经系统。脑池内注射SKF - 38393促使胎儿运动活动呈剂量依赖性增加，主要包括前肢、头部和躯干的运动。脑池内注射SCH - 23390不影响整体活动，但选择性地抑制前肢、后肢和头部运动，并促使口部动作、舔舐和面部擦拭增加。在脑池内注射SKF - 38393后给予SCH - 23390可有效完全逆转D1激动剂的行为效应。这些发现表明，对多巴胺D1受体的中枢操纵可对足月大鼠胎儿产生直接且强效的行为影响。
