Matsumoto K, Ojima K, Watanabe H
Division of Pharmacology, Research Institute for Wakan-Yaku (Oriental Medicines), Toyama Medical and Pharmaceutical University, Japan.
Pharmacol Biochem Behav. 1995 Mar;50(3):481-4. doi: 10.1016/0091-3057(94)00300-8.
The effects of denervation of central noradrenergic system on the desipramine-induced enhancement of aggressive behavior were examined in long-term isolated mice. Consistent with previous reports, desipramine (10 mg/kg, IP) significantly increased the duration of aggressive behavior in isolated mice. Pretreatment of isolated mice with DSP-4, a selective noradrenaline neurotoxin, significantly attenuated the enhancing effect of desipramine on aggressive behavior without affecting the basal aggressive responses. This effect appeared concomitant with decrease of noradrenaline levels in the cortex, hippocampus, cerebellum and hypothalamus (78%, 75%, 57%, and 17%, respectively). DSP-4 did not significantly affect dopamine or 5-HT levels in these regions. These results suggest that noradrenergic terminals originating mainly from the locus coeruleus play an important role in the desipramine enhancement of aggressive behavior, but not in the basal aggressive behavior of isolated mice.
在长期隔离饲养的小鼠中，研究了中枢去甲肾上腺素能系统去神经支配对地昔帕明诱导的攻击行为增强作用的影响。与之前的报道一致，地昔帕明（10mg/kg，腹腔注射）显著增加了隔离饲养小鼠的攻击行为持续时间。用选择性去甲肾上腺素神经毒素DSP-4对隔离饲养的小鼠进行预处理，可显著减弱地昔帕明对攻击行为的增强作用，且不影响基础攻击反应。这种作用伴随着皮质、海马、小脑和下丘脑去甲肾上腺素水平的降低（分别降低78%、75%、57%和17%）。DSP-4对这些区域的多巴胺或5-羟色胺水平没有显著影响。这些结果表明，主要源自蓝斑的去甲肾上腺素能终末在地昔帕明增强攻击行为中起重要作用，但对隔离饲养小鼠的基础攻击行为不起作用。
