Matsumoto K, Cai B, Satoh T, Ohta H, Watanabe H
Section of Pharmacology, Toyama Medical and Pharmaceutical University, Japan.
Pharmacol Biochem Behav. 1991 May;39(1):167-70. doi: 10.1016/0091-3057(91)90416-y.
Effects of desipramine on aggressive behavior induced by long-term (6-7 weeks) isolation of mice were examined. Aggressive behavior was measured as duration of biting attack and/or wrestling during a 20-min observation period. Desipramine (5, 10 and 20 mg/kg, IP) and imipramine (10 and 20 mg/kg, IP) dose-dependently increased the duration of aggressive behavior in isolated mice, without inducing aggressive behavior in group-housed animals. Desipramine-induced increase in aggressive behavior was blocked by phentolamine (3 mg/kg, IP) and yohimbine (0.3 mg/kg, IP), but not prazosin (0.5 mg/kg, IP). Clonidine (0.001 mg/kg, IP), an alpha 2 agonist, significantly blocked desipramine-induced enhancement of aggressive behavior in isolated mice without affecting the basal aggression. These data suggest that long-term isolation may induce functional changes in the sensitivity of alpha 2 receptor in the noradrenergic system and that desipramine enhancement of aggressive behavior in isolated mice is modulated by drugs acting onto alpha 2 noradrenergic receptors.
研究了去甲丙咪嗪对长期（6 - 7周）隔离小鼠诱导的攻击行为的影响。攻击行为通过在20分钟观察期内咬斗攻击和/或扭打的持续时间来衡量。去甲丙咪嗪（5、10和20毫克/千克，腹腔注射）和丙咪嗪（10和20毫克/千克，腹腔注射）剂量依赖性地增加了隔离小鼠攻击行为的持续时间，而在群居动物中未诱发攻击行为。酚妥拉明（3毫克/千克，腹腔注射）和育亨宾（0.3毫克/千克，腹腔注射）可阻断去甲丙咪嗪诱导的攻击行为增加，但哌唑嗪（0.5毫克/千克，腹腔注射）则不能。α2激动剂可乐定（0.001毫克/千克，腹腔注射）可显著阻断去甲丙咪嗪诱导的隔离小鼠攻击行为增强，而不影响基础攻击行为。这些数据表明，长期隔离可能会导致去甲肾上腺素能系统中α2受体敏感性的功能变化，并且去甲丙咪嗪增强隔离小鼠攻击行为是由作用于α2去甲肾上腺素能受体的药物调节的。
