Naruse T, Ishii R
Central Research Laboratories, Maruho Co., Ltd., Osaka, Japan.
Pharmacol Biochem Behav. 1995 Aug;51(4):923-7. doi: 10.1016/0091-3057(95)00081-7.
We investigated whether histaminergic neurons in the brain are involved in diazepam-induced hyperphagia in rats. Pretreatment with intracerebroventricular (ICV) injection of either histamine H1-receptor antagonist, pyrilamine (10 and 30 micrograms) or histamine H2-receptor antagonist, famotidine (3 and 10 micrograms) did not affect only diazepam (1 mg/kg, subcutaneous, SC)-induced hyperphagia in nondeprived rats, but also spontaneous feeding in food-deprived rats. In addition, pretreatment with ICV injection of histamine H3-receptor antagonist, thioperamide, and histamine H3-receptor agonist, (R) alpha methylhistamine, enhanced and inhibited diazepam-induced hyperphagia (1 mg/kg, SC) in nondeprived rats, respectively. However, thioperamide and (R) alpha methylhistamine did not affect spontaneous feeding in food-deprived rats. These findings suggest that histaminergic neurons are not directly involved in diazepam-induced hyperphagia in rats. Furthermore, enhancement or inhibition of diazepam-induced hyperphagia by histamine H3-receptor antagonist or agonist may occur via histamine H3-receptors localized in the other neurons in the rat brain.
我们研究了大脑中的组胺能神经元是否参与了地西泮诱导的大鼠食欲亢进。脑室内（ICV）注射组胺H1受体拮抗剂吡苄明（10微克和30微克）或组胺H2受体拮抗剂法莫替丁（3微克和10微克）进行预处理，不仅不会影响地西泮（1毫克/千克，皮下注射，SC）诱导的非剥夺大鼠食欲亢进，也不会影响食物剥夺大鼠的自发进食。此外，脑室内注射组胺H3受体拮抗剂硫代哌啶和组胺H3受体激动剂（R）α-甲基组胺进行预处理，分别增强和抑制了非剥夺大鼠地西泮诱导的食欲亢进（1毫克/千克，SC）。然而，硫代哌啶和（R）α-甲基组胺并不影响食物剥夺大鼠的自发进食。这些发现表明，组胺能神经元并不直接参与地西泮诱导的大鼠食欲亢进。此外，组胺H3受体拮抗剂或激动剂对 地西泮诱导的食欲亢进的增强或抑制作用可能是通过大鼠脑中其他神经元上的组胺H3受体实现的。
