Verotta L, Aburjai T, Rogers C B, Dorigo P, Maragno I, Fraccarollo D, Santostasi G, Gaion R M, Floreani M, Carpenedo F
Planta Med. 1995 Jun;61(3):271-4. doi: 10.1055/s-2006-958071.
Two alkaloids 1 and 2 were isolated from the seeds of Erythrophleum lasianthum. Their structures were assigned by spectroscopic and chemical means as 3 beta-hydroxynorerythrosuamine (1) and its 3-O-beta-D-glucopyranoside (2). In spontaneously beating atria, both compounds 1 and 2 showed a marked and concentration-dependent positive inotropic activity and a weak negative chronotropic activity. The positive inotropic effect induced by 1 and 2 was not modified by propranolol, prazosin, carbachol, and ranitidine plus pyrilamine. Both 1 and 2 were very active in inhibiting the Na+/K(+)-ATPase isolated from bovine cardiac sarcolemmal vesicles.
从毛叶蕊木种子中分离出两种生物碱1和2。通过光谱和化学方法确定它们的结构分别为3β-羟基去甲赤藓胺（1）及其3-O-β-D-吡喃葡萄糖苷（2）。在自发性搏动的心房中，化合物1和2均表现出显著的、浓度依赖性的正性肌力活性和较弱的负性变时活性。1和2诱导的正性肌力作用不受普萘洛尔、哌唑嗪、卡巴胆碱以及雷尼替丁加吡咯胺的影响。1和2在抑制从牛心肌肌膜囊泡分离出的Na+/K(+)-ATP酶方面都非常有效。
