Piraino Neuenschwander P, Pumarino Carte H, Bidegain González F, Zura Jiménez M L, Ferreiro Merino F
Departamento de Medicina, Hospital Clínico de la Universidad de Chile José Joaquín Aguirre, Santiago.
Rev Clin Esp. 1995 May;195(5):294-7.
Thyrotoxic periodic paralysis (TPP) is a rare complication of thyrotoxicosis in whites but it is commonly reported in oriental populations. Eighteen males with TPP were studied from 1966 to 1993 (17 years) with a mean age of 32.8 years (range: 22-50 years). Their ancestor, traced back as possible, was hispanic in 15 and autoctonous indigens (mapuche) in three. They had one or more episodes of flaccid paralysis with complete recovery associated with thyrotoxicosis and hypokalemia (in the twelve patients who had their serum potassium determined). Two patients had respiratory compromise. Ten patients had their crisis onset after physical exertion and/or copious ingestion of carbohydrates. Only one of the patients had severe thyrotoxicosis and the diagnosis was made after the periodic paralysis in ten of them. The types of thyrotoxicosis associated with TPP were: Graves-Basedow disease in 13, subacute thyroitidis in three, and overdosage of thyroid hormone in two patients. In summary, TPP can occur in latin american populations, may be fatal, and is not always associated with Graves-Basedow disease.
甲状腺毒症性周期性瘫痪（TPP）在白人中是甲状腺毒症的一种罕见并发症，但在东方人群中却常有报道。1966年至1993年（共17年）对18例TPP男性患者进行了研究，他们的平均年龄为32.8岁（范围：22至50岁）。尽可能追溯其祖先，其中15人的祖先是西班牙裔，3人的祖先是当地原住民（马普切人）。他们有一次或多次弛缓性麻痹发作，发作后完全恢复，且与甲状腺毒症和低钾血症相关（12例测定了血清钾的患者）。2例患者出现呼吸功能不全。10例患者在体力活动和/或大量摄入碳水化合物后发生危象。只有1例患者患有严重甲状腺毒症，其中10例在周期性瘫痪后才做出诊断。与TPP相关的甲状腺毒症类型为：格雷夫斯-巴塞多病13例，亚急性甲状腺炎3例，2例患者甲状腺激素过量。总之，TPP可发生于拉丁美洲人群，可能致命，且并不总是与格雷夫斯-巴塞多病相关。
