Shijubo N, Fujishima T, Ooashi K, Morita S, Shigehara K, Nakata H, Abe S
Third Department of Internal Medicine, Sapporo Medical University School of Medicine, Japan.
Sarcoidosis. 1995 Mar;12(1):71-4.
A 36-year-old housewife was referred to our hospital in March, 1993. Her chest X ray films showed mediastinal and bilateral hilar lymphadenopathy. She was confirmed to have pulmonary sarcoidosis. We did not administer any medications for her. Four months after the diagnosis of sarcoidosis, opacities with cavitation appeared on the chest X ray. Histologic findings of lung biopsy specimens revealed granulomas with the existence of encapsulated Cryptococci. We administered an antifungal drug, itraconazole. The opacities were greatly improved by the medication. We report focal pulmonary cryptococcal infection in an untreated patient with sarcoidosis.
一名36岁的家庭主妇于1993年3月被转诊至我院。她的胸部X光片显示纵隔及双侧肺门淋巴结肿大。她被确诊为肺结节病。我们未对她使用任何药物治疗。在结节病诊断四个月后，胸部X光片上出现了伴有空洞形成的混浊影。肺活检标本的组织学检查结果显示肉芽肿内存在被包裹的隐球菌。我们给予了抗真菌药物伊曲康唑治疗。用药后混浊影明显改善。我们报告了一例未经治疗的结节病患者发生局灶性肺隐球菌感染的病例。
