雄性大鼠肝脏对降血脂药物氯贝酸敏感性的年龄相关变化。

Age-related changes in the susceptibility to clofibric acid, a hypolipidemic agent, of male rat liver.

作者信息

Yamoto T, Ohashi Y, Teranishi M, Takaoka M, Manabe S, Matsunuma N, Makita T

机构信息

Laboratory Animal Science, Sankyo Co. Ltd., Shizuoka, Japan.

出版信息

Toxicol Lett. 1995 Jul;78(2):141-5. doi: 10.1016/0378-4274(94)03247-5.

DOI:10.1016/0378-4274(94)03247-5

PMID:7618179

Abstract

Age-related changes in the susceptibility to clofibric acid were investigated in male F344 rats of 8, 52, and 117 weeks old. Hepatomegaly, decrease of serum total cholesterol and triglyceride, increase of the total cytochrome P-450 contents, induction of the activities of microsomal omega-hydroxylation and peroxisomal beta-oxidation, proliferation of smooth endoplasmic reticulum and peroxisomes were detected in 8- and 52-week-old rats. In 117-week-old rats clofibric acid treatment resulted in decrease of serum total cholesterol, elevation of the activities of microsomal and peroxisomal enzymes, and slight proliferation of peroxisomes. These results suggest that the susceptibility of the male F344 rat liver to clofibric acid decreases in 117-week-old rats, though the effect is still recognizable.

摘要

研究了8周龄、52周龄和117周龄雄性F344大鼠对氯贝酸敏感性的年龄相关变化。在8周龄和52周龄大鼠中检测到肝肿大、血清总胆固醇和甘油三酯降低、总细胞色素P-450含量增加、微粒体ω-羟基化和过氧化物酶体β-氧化活性诱导、滑面内质网和过氧化物酶体增殖。在117周龄大鼠中，氯贝酸治疗导致血清总胆固醇降低、微粒体和过氧化物酶体酶活性升高以及过氧化物酶体轻度增殖。这些结果表明，117周龄大鼠雄性F344大鼠肝脏对氯贝酸的敏感性降低，尽管这种影响仍然可以识别。