Yamoto T, Ohashi Y, Furukawa T, Teranishi M, Manabe S, Makita T
Laboratory Animal Science and Toxicology Laboratories, Sankyo Co. Ltd., Shizuoka, Japan.
Toxicol Lett. 1996 May;85(2):77-83. doi: 10.1016/0378-4274(96)03643-0.
Although it has been reported that male rats are more responsive than females to peroxisome proliferation induced by clofibrate, these sex differences have been confirmed in young adult rats. Using 4-, 8-, and 12-week-old F344 rats, postnatal change of the sex-dependent response to clofibrate was investigated. These animals were administered 200 mg/kg body wt./day clofibrate by gavage for 7 days. In 4-week-old rats clofibrate-dependent changes (hepatomegaly, induction of hepatic microsomal and peroxisomal enzymes, proliferation of smooth endoplasmic reticulum and peroxisomes of hepatocytes) were slight in both sexes. In 8- and 12-week-old rats clofibrate-induced changes of males were moderate, whereas those of females were slight. These results suggest that the responsiveness of immature rat to clofibrate is weak and in males the susceptibility is gradually strong during postnatal development.
虽然有报道称雄性大鼠比雌性大鼠对氯贝丁酯诱导的过氧化物酶体增殖反应更敏感，但这些性别差异在年轻成年大鼠中得到了证实。使用4周龄、8周龄和12周龄的F344大鼠，研究了对氯贝丁酯的性别依赖性反应的出生后变化。这些动物通过灌胃给予200mg/kg体重/天的氯贝丁酯，持续7天。在4周龄的大鼠中，氯贝丁酯依赖性变化（肝肿大、肝微粒体和过氧化物酶体酶的诱导、肝细胞滑面内质网和过氧化物酶体的增殖）在两性中都很轻微。在8周龄和12周龄的大鼠中，氯贝丁酯诱导的雄性大鼠变化中等，而雌性大鼠变化轻微。这些结果表明，未成熟大鼠对氯贝丁酯的反应性较弱，并且在出生后发育过程中，雄性大鼠的易感性逐渐增强。
