Theories on the metastatic process and possible therapeutic options.

A sequence of steps are prerequisite for cancer cells before metastases are established. Metastasis has been shown to be an inefficient process limited by both random and selective events. By differentiating invasion from metastasis, sequential steps in the metastatic cascade have been defined and studied separately. This approach has yielded a variety of new potential therapeutic strategies. However, increasing knowledge of the mechanisms relating to metastasis has also revealed the complexity of each step. In spite of difficulties in translating results obtained in preclinical models into the clinical setting, continued development of such model systems and further research into the genetic control of metastatic dissemination will lead to improved strategies for prevention of metastasis formation and for treatment of metastatic tumor cells.