Cherkasova T D, Iurkiv V A
Vopr Med Khim. 1994 Nov-Dec;40(6):17-20.
Yersinia pestis toxin (II fraction by E. Baker) inhibited aggregation of human platelets as well as elevation of Ca2+, induced by different agonists ADP, PAF, thrombin. Agonist-induced Ca2+ mobilization and Ca2+ influx were dose-dependently inhibited by the toxin. The effect was rapid, developing during the first minute of incubation with the toxin. In contrast to murine lethal protein the platelet inhibitory activity was thermostable. The action of thermostable factor on platelets was accompanied by elevation of cellular cGMP level. This factor of Y. pestis activated guanylate cyclase in human platelets.
鼠疫耶尔森菌毒素（E. 贝克的II组分）抑制人血小板聚集以及由不同激动剂ADP、PAF、凝血酶诱导的Ca2+升高。该毒素剂量依赖性地抑制激动剂诱导的Ca2+动员和Ca2+内流。这种作用迅速，在与毒素孵育的第一分钟内就会出现。与鼠致死蛋白不同，血小板抑制活性是热稳定的。热稳定因子对血小板的作用伴随着细胞cGMP水平的升高。鼠疫耶尔森菌的这种因子激活了人血小板中的鸟苷酸环化酶。
