Cherkasova G D, Bochkov V N, Iurkiv V A, Pokrovskiĭ V I
Biull Eksp Biol Med. 1993 Nov;116(11):527-9.
Thermostable protein factor (20000 Da) was prepared from Yersinia pestis avirulent strain EV 1290. This protein inhibited the aggregation of human platelets as well as elevation of [Ca2+], induced by different agonist. The action of this protein on platelets is accompanied by elevation of cellular cGMP levels. This factor activated guanylate cyclase suspension of human platelets. The data indicate that this protein factor of Y. pestis may possibly release in circulation during decay of bacteria and can change the physiological activity of human blood cells and contribute to the pathogenesis of plague.
从鼠疫耶尔森菌无毒株EV 1290中制备出了热稳定蛋白因子（20000道尔顿）。该蛋白可抑制人血小板聚集以及不同激动剂诱导的[Ca2+]升高。此蛋白对血小板的作用伴随着细胞cGMP水平的升高。该因子可激活人血小板鸟苷酸环化酶悬浮液。数据表明，鼠疫耶尔森菌的这种蛋白因子可能在细菌分解过程中释放到循环系统中，进而改变人体血细胞的生理活性并促使鼠疫发病。
