Sandbank M, Ben-David E
Int J Dermatol. 1979 Jan-Feb;18(1):50-4. doi: 10.1111/j.1365-4362.1979.tb01912.x.
Biopsy material in early and late stages of cutaneous leishmaniasis was obtained. The ultrastructural study using acid phosphatase reaction as a marker for lysosomes showed that in early stages parasites proliferate undisturbed within macrophage cytoplasm. At later stages numerous degenerating parasites were seen and macrophage lysosomes were observed adhering to and pouring their contents into the parasite. It is assumed that activated macrophages control intracellular parasitism by lysosomal activity.
获取了皮肤利什曼病早期和晚期的活检材料。以酸性磷酸酶反应作为溶酶体标记物的超微结构研究表明，在早期阶段，寄生虫在巨噬细胞胞质内不受干扰地增殖。在后期阶段，可见大量退化的寄生虫，并且观察到巨噬细胞溶酶体附着在寄生虫上并将其内容物倒入寄生虫中。据推测，活化的巨噬细胞通过溶酶体活性控制细胞内寄生。
