Brazil R P
Ann Trop Med Parasitol. 1984 Apr;78(2):87-91. doi: 10.1080/00034983.1984.11811781.
The in vivo infection of murine peritoneal macrophages by promastigotes of infective and non-infective isolates of Leishmaniasis mexicana ssp. was studied. Ultrastructural observations showed that lysosomes fuse with phagosomes containing Leishmania parasites. Intracellular parasites always occurred within phagosomes and there was no evidence of direct contact with host cytoplasm. The behaviour of infective parasites within macrophages resembled that described for a non-infective isolate. The presence of lysosomal marker in the phagosomes confirms previous findings in vitro.
研究了墨西哥利什曼原虫感染性和非感染性分离株的前鞭毛体对小鼠腹腔巨噬细胞的体内感染情况。超微结构观察表明，溶酶体与含有利什曼原虫寄生虫的吞噬体融合。细胞内寄生虫总是出现在吞噬体内，没有证据表明其与宿主细胞质直接接触。巨噬细胞内感染性寄生虫的行为与非感染性分离株所描述的相似。吞噬体内溶酶体标记物的存在证实了先前的体外研究结果。
