Nilsson S, Wikström M, Martinussen H J, Ericsson A, Wikström G, Waldenström A, Oksendal A N, Hemmingsson A
Department of Diagnostic Radiology, University Hospital, Uppsala, Sweden.
Acta Radiol. 1995 Jul;36(4):338-45.
The aim of this study was to investigate whether dysprosium (Dy) induced signal intensity (SI) loss in infarcted tissue in MR imaging. Myocardial infarction was induced in 12 pigs and Dy-DTPA-BMA (1.0 mmol/kg b.w.) was administered i.v. to 6 pigs 4 hours after occlusion and allowed to accumulate in the infarctions for 2 hours. Dy was analysed by inductively coupled plasma atomic emission spectrometry in infarcted and non-ischaemic tissue samples. The remaining 6 pigs, not administered contrast medium, served as controls. The infarctions demonstrated a high SI in the proton density- and T2-weighted sequences in both groups (ex vivo), although the Dy-DTPA-BMA group demonstrated a 3-fold greater concentration of Dy in infarcted compared with non-ischaemic myocardium. The lack of SI loss after Dy accumulation indicates that susceptibility effects are minor or absent in infarcted myocardium.
本研究的目的是调查钬（Dy）在磁共振成像中是否会导致梗死组织信号强度（SI）降低。对12头猪诱导产生心肌梗死，在闭塞4小时后对6头猪静脉注射钬-二乙三胺五乙酸-双甲基酰胺（Dy-DTPA-BMA，1.0 mmol/kg体重），使其在梗死灶中蓄积2小时。通过电感耦合等离子体原子发射光谱法分析梗死组织和非缺血组织样本中的钬。其余6头未注射造影剂的猪作为对照。两组梗死灶在质子密度加权和T2加权序列中均显示高信号强度（离体），尽管与非缺血心肌相比，Dy-DTPA-BMA组梗死灶中的钬浓度高3倍。钬蓄积后信号强度未降低，表明梗死心肌中的磁化率效应较小或不存在。
