Nilsson S, Wikström M, Ericsson A, Wikström G, Waldenström A, Oksendal A, Hemmingsson A
Department of Diagnostic Radiology, University Hospital, Uppsala, Sweden.
Acta Radiol. 1995 Jul;36(4):346-52.
MR imaging was performed to investigate whether Gd-DTPA-BMA-induced contrast enhancement of myocardial infarction is counteracted by Dy-DTPA-BMA. Myocardial infarction was induced in 5 pigs. Microdialysate probes were inserted in ischemic and nonischemic myocardium. Gd-DTPA-BMA (0.3 mmol/kg b.w.) and Dy-DTPA-BMA (1.0 mmol/kg b.w.) were administered i.v. 4 hours post occlusion. The microdialysate was collected every 10 min and measured for Gd and Dy using inductively coupled plasma atomic emission spectrometry. The pigs were sacrificed 2 hours after administration of contrast media. The concentration of both contrast agents was 3 times higher in infarcted myocardium than in nonischemic myocardium. The infarctions displayed high signal intensity in spin-echo sequences ex vivo. This lack of detectable susceptibility effects from Dy may be caused by loss of cell membrane integrity in infarcted tissue as shown by our microdialysate and biopsy data.
进行磁共振成像以研究钆喷酸葡胺-双甲基乙酰胺（Gd-DTPA-BMA）诱导的心肌梗死对比增强是否会被镝喷酸葡胺-双甲基乙酰胺（Dy-DTPA-BMA）抵消。对5头猪诱导心肌梗死。将微透析探针插入缺血和非缺血心肌中。在闭塞后4小时静脉注射钆喷酸葡胺-双甲基乙酰胺（0.3 mmol/kg体重）和镝喷酸葡胺-双甲基乙酰胺（1.0 mmol/kg体重）。每10分钟收集一次微透析液，并使用电感耦合等离子体原子发射光谱法测量钆和镝。在注射造影剂后2小时处死猪。梗死心肌中两种造影剂的浓度均比非缺血心肌高3倍。梗死灶在离体自旋回波序列中显示高信号强度。如我们的微透析和活检数据所示，镝缺乏可检测到的磁化率效应可能是由于梗死组织中细胞膜完整性丧失所致。
