Popescu A, Cernescu C
Stefan S. Nicolau Institute of Virology, Bucharest, Romania.
Rev Roum Virol. 1994 Jul-Dec;45(3-4):203-9.
Earlier work has shown that HIV binding to CD 4 is necessary, but apparently not sufficient, for viral entry into cells. Several molecules have been proposed as potential candidates for coreceptors in HIV infection. Remarkable attention and criticism was raised by the report of Hovanessian group from Pasteur Institute, France, which claimed the role of CD 26, an enzyme also known as dipeptidyl peptidase IV, as cofactor in HIV entry and HIV infection. Present review mentions some reports which support or reject this hypothesis.
早期研究表明，HIV与CD4的结合对于病毒进入细胞是必要的，但显然并不充分。已经提出了几种分子作为HIV感染中辅助受体的潜在候选者。法国巴斯德研究所的霍瓦内西安小组的报告引起了极大关注和批评，该报告称CD26（一种也称为二肽基肽酶IV的酶）在HIV进入和HIV感染中作为辅助因子发挥作用。本综述提及了一些支持或反驳这一假说的报告。
