Figueiredo M S, Silva M C, Guerreiro J F, Souza G P, Pires A C, Zago M A
Departamento de Clínica Médica, Faculdade de Medicina, Ribeirão Preto, Brasil.
Gene Geogr. 1994 Apr;8(1):7-12.
The beta s cluster haplotypes were determined for 74 Brazilian patients with sickle cell anemia from three cities separated by 1,400 to 2,300 km. The cities are representative of the regions which have the largest Black populations of the country. All 138 chromosomes with typical haplotypes had one of the three most common African haplotypes. No example of the Asian or of the Cameroon haplotypes was found. The Bantu haplotype predominates in all three regions (54.8 to 73.1%), followed by the Benin haplotype (25.4 to 45.2%) and a small number of cases with the Senegal haplotype (0 to 6.9%). The mean prevalence of the Bantu haplotype of 65.9% agrees closely with historical data which indicate that 70% of the African slaves brought to Brazil originated from regions of Bantu populations.
对来自三个相距1400至2300公里的城市的74名巴西镰状细胞贫血患者的βs簇单倍型进行了测定。这些城市代表了该国黑人人口最多的地区。所有138条具有典型单倍型的染色体都属于三种最常见的非洲单倍型之一。未发现亚洲或喀麦隆单倍型的例子。班图单倍型在所有三个地区占主导地位（54.8%至73.1%），其次是贝宁单倍型（25.4%至45.2%），还有少数塞内加尔单倍型病例（0至6.9%）。班图单倍型的平均流行率为65.9%，与历史数据非常吻合，历史数据表明，被带到巴西的非洲奴隶中有70%来自班图人口地区。
