哥伦比亚的镰状细胞贫血与β-珠蛋白基因簇单倍型

Sickle cell anemia and beta-globin gene cluster haplotypes in Colombia.

作者信息

Cuéllar-Ambrosi F, Mondragón M C, Figueroa M, Préhu C, Galactéros F, Ruiz-Linares A

机构信息

Sección de Hematologia, Departamento de Medicina Interna, Facultad de Medicina, Universidad de Antioquia, Medellin, Colombia.

出版信息

Hemoglobin. 2000 Aug;24(3):221-5. doi: 10.3109/03630260008997529.

DOI:10.3109/03630260008997529

PMID:10975441

Abstract

We studied 46 unrelated sickle cell anemia patients from the western region of Colombia which has the largest Black population of the country. Twenty-three children and 23 adults were studied. The distribution of haplotypes in the children was 58% Bantu, 38% Benin, and 4% Senegal, and in the adults it was 59.4% Bantu, 35.1% Benin, and 5.5% Senegal (p = 0.920). All 92 chromosomes had typical African haplotypes, Bantu 55.5%, Benin 34.8%, Senegal, 4.3%, and Cameroon, 5.4%. Our results suggest a lack of differential survival among patients with sickle cell anemia and typical beta-globin gene cluster haplotypes. They also agree closely with historical data that indicate that most African slaves brought to Colombia originated from Angola (Bantu population) and the Sao Thomó Island in the Bight of Benin (Central West Africa).

摘要

我们研究了来自哥伦比亚西部地区的46名非亲属镰状细胞贫血患者，该国西部地区拥有全国最大的黑人人口。研究对象包括23名儿童和23名成年人。儿童中单倍型的分布为：班图型58%，贝宁型38%，塞内加尔型4%；成年人中则为：班图型59.4%，贝宁型35.1%，塞内加尔型5.5%（p = 0.920）。所有92条染色体均具有典型的非洲单倍型，其中班图型55.5%，贝宁型34.8%，塞内加尔型4.3%，喀麦隆型5.4%。我们的研究结果表明，镰状细胞贫血患者与典型β-珠蛋白基因簇单倍型之间不存在生存差异。这些结果也与历史数据高度吻合，历史数据表明，被带到哥伦比亚的大多数非洲奴隶来自安哥拉（班图人群）和贝宁湾的圣多美岛（中西部非洲）。