Bradley C M, Alderman B W, Williams M A, Checkoway H, Fernbach S K, Greene C, Bigelow P L, Reif J S
Department of Epidemiology, University of Washington, Seattle, USA.
Epidemiology. 1995 May;6(3):306-10. doi: 10.1097/00001648-199505000-00020.
In a population-based case-control study, we examined relations between maternal and paternal occupations and the risk of infant craniosynostosis. Cases were 212 children born to Colorado residents and diagnosed during 1986-1989 with radiographically confirmed synostosis of unknown etiology. Controls were 291 children randomly selected from state birth records and frequency matched to cases on month and year of birth. Trained staff conducted telephone interviews of mothers of case and control children. Information was obtained about each job held by either parent during the pregnancy, and any job that the father held during the 3 months before the last menstrual period before conception. Jobs were coded using 1980 Census occupation and industry codes. We found no strong associations for maternal occupations. Of paternal occupations, two groups were associated with moderately increased odds ratios after adjustment for maternal smoking and altitude: agriculture and forestry (odds ratio = 2.3; 95% confidence interval = 1.0-5.2), and mechanics and repairmen (odds ratio = 2.7; 95% confidence interval = 1.2-6.1). For both, the odds ratios were higher for males.
在一项基于人群的病例对照研究中，我们研究了母亲和父亲的职业与婴儿颅缝早闭风险之间的关系。病例为212名科罗拉多州居民所生的儿童，他们于1986年至1989年期间被诊断为病因不明的经放射学证实的颅缝早闭。对照为从该州出生记录中随机选取的291名儿童，在出生月份和年份上与病例进行频数匹配。经过培训的工作人员对病例组和对照组儿童的母亲进行了电话访谈。获取了父母双方在孕期从事的每一份工作以及父亲在受孕前最后一次月经前3个月内从事的任何工作的信息。工作采用1980年人口普查职业和行业代码进行编码。我们未发现母亲职业有显著关联。在父亲的职业中，经调整母亲吸烟情况和海拔因素后，有两组职业的比值比适度升高：农业和林业（比值比 = 2.3；95%置信区间 = 1.0 - 5.2），以及机械师和修理工（比值比 = 2.7；95%置信区间 = 1.2 - 6.1）。对于这两组职业，男性的比值比更高。
