Hadigan C M, Walsh B T, Buttinger C, Hollander E
New York State Psychiatric Institute, NY 10032, USA.
Biol Psychiatry. 1995 Apr 15;37(8):504-11. doi: 10.1016/0006-3223(94)00169-4.
In response to the partial serotonin agonist meta-chlorophenylpiperazine (metaCPP), patients with obsessive-compulsive disorder have been reported to exhibit an increase in obsessive symptoms and a diminished release of prolactin and/or cortisol compared to controls. We examined the response to metaCPP of 10 patients with anorexia nervosa, before and after weight gain, and of eight healthy controls. Prior to weight gain, the patients exhibited a greater behavioral response to metaCPP than the controls and diminished prolactin and cortisol responses. Only the prolactin abnormality persisted after weight gain. These observations suggest that, in patients with anorexia nervosa, weight loss is associated with the development of neurobiological disturbances which are in some ways similar to those of obsessive-compulsive disorder.
据报道，与对照组相比，强迫症患者在对部分血清素激动剂间氯苯哌嗪（metaCPP）产生反应时，强迫症状会加重，催乳素和/或皮质醇的释放会减少。我们研究了10名神经性厌食症患者在体重增加前后对metaCPP的反应，以及8名健康对照者对metaCPP的反应。在体重增加之前，患者对metaCPP的行为反应比对照组更强烈，催乳素和皮质醇反应减弱。体重增加后，只有催乳素异常持续存在。这些观察结果表明，在神经性厌食症患者中，体重减轻与神经生物学紊乱的发生有关，这些紊乱在某些方面与强迫症的紊乱相似。
