Garcia-Borreguero D, Jacobsen F M, Murphy D L, Joseph-Vanderpool J R, Chiara A, Rosenthal N E
National Institute of Mental Health, Clinical Psychobiology Branch, Bethesda, MD 20892, USA.
Biol Psychiatry. 1995 May 15;37(10):740-9. doi: 10.1016/0006-3223(94)00208-K.
We report on the plasma cortisol and prolactin responses to the serotonergic agonist m-CPP (0.1 mg/kg) in 10 patients with winter seasonal affective disorder (SAD) and 10 controls during the winter, in both untreated and bright light-treated conditions; and on 8 other SAD patients and 8 other controls during the summer. Following m-CPP infusion, untreated patients had exaggerated prolactin (p < .05) and cortisol (p < .05) responses compared to controls. Light treatment significantly reduced responses of both hormones to m-CPP (prolactin: p < .01; cortisol: p < .01). When untreated winter subjects and summer subjects were compared, cortisol, but not prolactin responses to m-CPP were found to be higher in patients than in controls during the winter, and lower in patients than in controls during the summer (diagnosis by season: p < .05). These results are consistent with those of our previous report on the behavioral responses to m-CPP in the same patients and suggest an abnormality in serotonergic function in untreated SAD patients in winter, which is normalized following treatment with light therapy and naturally during the summer.
我们报告了10例冬季季节性情感障碍（SAD）患者和10例对照在冬季未治疗及接受明亮光线治疗条件下，以及另外8例SAD患者和8例对照在夏季，对血清素能激动剂间氯苯哌嗪（m-CPP，0.1mg/kg）的血浆皮质醇和催乳素反应。输注m-CPP后，与对照相比，未治疗患者的催乳素（p<0.05）和皮质醇（p<0.05）反应增强。光线治疗显著降低了两种激素对m-CPP的反应（催乳素：p<0.01；皮质醇：p<0.01）。当比较冬季未治疗的受试者和夏季受试者时，发现冬季患者对m-CPP的皮质醇反应高于对照，而催乳素反应无差异，夏季患者对m-CPP的反应低于对照（按季节诊断：p<0.05）。这些结果与我们之前关于同一患者对m-CPP行为反应的报告结果一致，提示冬季未治疗的SAD患者血清素能功能异常，经光线治疗后及夏季自然状态下可恢复正常。
