Beggs W H
VA Medical Center, Minneapolis, MN 55417, USA.
Res Commun Mol Pathol Pharmacol. 1995 Apr;88(1):115-8.
Tamoxifen, a drug used to treat breast cancer, might have antifungal potential. The fungicidal activity of tamoxifen against Candida albicans surpassed that of the most active of the imidazole-type drugs. At 15-20 microM, tamoxifen rapidly killed yeast cells in stationary phase as well as in logarithmic phase, whereas imidazoles at this level generally do not exert significant lethal activity against stationary phase organisms.
他莫昔芬是一种用于治疗乳腺癌的药物，可能具有抗真菌潜力。他莫昔芬对白色念珠菌的杀菌活性超过了活性最强的咪唑类药物。在15 - 20微摩尔浓度下，他莫昔芬能迅速杀死稳定期和对数期的酵母细胞，而在此浓度下咪唑类药物通常对稳定期生物体没有显著的致死活性。
