Beggs W H
VA Medical Center, Minneapolis, MN 55417.
Res Commun Chem Pathol Pharmacol. 1993 Apr;80(1):125-8.
Earlier workers found that tamoxifen, a drug widely used to treat breast cancer, can exert a marked antifungal action against the non-pathogenic yeast Saccharomyces cerevisiae. In this report, the earlier observation has been extended to Candida albicans, the most important of the opportunistic fungal pathogens. Experiments in which antifungal effect against logarithmic phase cells was monitored by viable count as a function of drug exposure time clearly showed that tamoxifen is highly fungicidal at 2.0 x 10(-5) M, moderately and transiently fungicidal at 1.0 x 10(-5) M, but only very weakly fungistatic at 5.0 x 10(-6) M.
早期的研究人员发现，他莫昔芬这种广泛用于治疗乳腺癌的药物，对非致病性酵母酿酒酵母具有显著的抗真菌作用。在本报告中，早期的观察结果已扩展至白色念珠菌，这是最重要的机会性真菌病原体。通过活菌计数监测对数期细胞的抗真菌效果，并将其作为药物暴露时间的函数进行实验，结果清楚地表明，他莫昔芬在2.0×10⁻⁵ M时具有高度杀菌作用，在1.0×10⁻⁵ M时具有中度且短暂的杀菌作用，但在5.0×10⁻⁶ M时仅具有非常微弱的抑菌作用。
